At least two decades of research have built a tower of evidence establishing that an active microbiome, derived from colony-forming probiotic systems and the prebiotic fermentable fibers and starches that support them, confers inestimable and comprehensive health benefits. Prebiotics are beneficial microbes that, when ingested in the form of cultured or fortified foods and beverages or as supplements either directly or indirectly (such as through the production of certain bioactive compounds lately termed “postbiotics”) support health. Combinations of prebiotics and probiotics that have been tailored for each other are referred to as synbiotics.

Postbiotics are produced by the probiotic metabolization of prebiotic fibers and starches and breakdown of the microbes themselves. They include vitamins B12 and K, beneficial short-chain fatty acids (butyrate, propionate, acetate), plus certain polysaccharides and amino acid fractions.

All of these products, in whole and in part, have demonstrated through scientific research to provide a comprehensive toolbox of health benefits that include:

Digestive Health

Extensive research has been conducted on probiotic supplementation benefits and the improvement of digestive health. The addition of prebiotics, the fermentable fibers and starches that feed the probiotics alone can improve gut health however, a supplementation of pre- and probiotics has been the most effective at improving gut health across the lifespan. Supplementation of the diet with probiotics and prebiotics can dramatically improved luminal integrity, absorption, and metabolism while reducing inflammation and having a direct impact on reduction in metabolic disorders.

Strains:
iVS-1® | IMC 501 and IMC 502 | SP1 | BLC1 | HN019

Client Note: Strains will link to corresponding pages

Immunity

It has been firmly established that a healthy digestive system is a fundamental component of the total immune system. Research has demonstrated that ingestion of pre- and probiotics improve plasma levels of interleukins and reduce gastrointestinal discomfort. Postbiotic compounds can help improve and modulate neurophysiology and immunity. Research supports commensal microbes as providing stability in the gut environment and being among the most pivotal defenses against pathogenic organisms.

Strains:
CRL 1505™ | BLC1 | BI-04 | SP1 | HN019 | HN001 | iVS-1®

Women’s Health

Multiple facets of women’s health are positively affected by a healthy microbiome. Recent research has been paying special attention to the vaginal microbiota and their ability, when in balance, to protect against yeast infections, bacterial overgrowth, and even reduce risk of certain cancers. Supplementation of probiotics with complementary prebiotics during pregnancy has been shown to help reduce the opportunity for obesity in offspring, and pregnant women have exhibited improvement in insulin-resistance when supplemented with prebiotics.

Strains:
CA15

Early Life (Infants and Toddlers)

There is a direct link to the impact of the gut microbiome and behavioral health in infants birthed through the birth canal. Pre- and probiotics have a positive impact on infant gut health and development. Meanwhile, postbiotics are able to cross the blood brain barrier and have demonstrated aiding in improved brain function and microglia function prior to birth and into adulthood, resulting in greater regulation of inflammatory responses, improved total immune recovery, and reduction in neurological diseases across the lifespan.

Strains:
LR92 | HN001 | CRL 1505™ | SP1 |BLC1

Children’s Health

Supplementation with probiotics has shown strong evidence of helping to reduce incidence of childhood asthma. In children with Autism, supplementation with probiotics could improve gastrointestinal symptoms associated with the disorder, and in children in general could regulate inflammatory responses and lead ultimately to improvements in social behavior in children. Supplementation with postbiotics have been investigated for supporting a positive impact on reduction of autism symptoms in children.

Strains:
LR92 | HN001 | CRL 1505™ | SP1 | BLC1

Cognitive Health (Memory and Mood)

Supplementation with certain probiotic bacteria appeared to improve serotonin transmission in adults. Symptoms of Alzheimer’s disease have been alleviated in patients supplemented with both selenium and probiotics. Other interactions, such as the gut-brain axis, have a continuous feedback loop with one another. Vagal nerve stimulation can improve or cause dysbiosis in gut microbiota. Dysbiosis and neurodevelopment disorders have a direct link to where symptoms have shown to be improved with probiotic supplementation.

Strains:
L. plantarum P8 | DR7®

Healthy Aging

Reductions in key beneficial bacteria have been reported in aging adults as a result of lifestyle, environmental, and diet changes. Lowered enteric nervous system integrity has an undeniable negative impact on cognitive health and aging. Supplementation with select probiotics, in addition to boosting immune function, has been associated with improvement in dysfunctions specifically associated with aging. Probiotics and prebiotics can improve aid in cognitive function and memory while reducing inflammation, depression, and neural degeneration.

Strains:
iVS-1®

Metabolic Health

Current research reports a positive relationship between probiotics, prebiotics, gut health, and metabolic health. Combinations of select probiotic bacteria are effective at improving intestinal epithelial integrity, while mitigating symptoms of diabetes mellitus, obesity, and chronic inflammation. Different combinations of pre-, pro-, and postbiotics confer their health benefits on the host dependent upon the disorder and ratio in which they are supplemented.

Strains:
iVS-1®